Side A · Liner notes
Unveiling the Striking Contrasts in Glycolic Acid Production
Skincare · Words by Lorraine Dallmeier · Released
Discover how fermentation-derived glycolic acid redefines skincare by offering a purer, less irritating option compared to traditional methods using formaldehyde.

Glycolic acid has held a prominent place in skincare formulations since its introduction in the 1930s. Initially developed by DuPont, this alpha hydroxy acid (AHA) is famed for its exfoliating properties, making it a staple in products ranging from drugstore toners to professional peels. However, the production methods have largely remained unchanged, relying on formaldehyde, a chemical that many modern consumers would prefer to avoid. The ongoing conversation around its sourcing has gained new intensity, especially following the resurgence of glycolic acid popularity during the pandemic, largely driven by The Ordinary’s viral 30% glycolic acid peel.

The New Player in Glycolic Acid
In the latest episode of Green Beauty Conversations, host Lorraine Dallmeier speaks with Vikram Pandit, co-founder and CEO of Phycus Biotechnologies. The Canadian company has launched a pioneering product: the world’s first commercially available fermentation-derived glycolic acid, named Purolic Acid. This innovative version not only meets consumer demand for cleaner, greener ingredients but also showcases the impact of sourcing and manufacturing methods on skincare.

Understanding Glycolic Acid Composition
The crux of the discussion revolves around the surprising fact that although both conventional and fermentation-derived glycolic acid have identical molecular structures, they can behave differently on the skin. The key lies in their impurity profiles. Conventional glycolic acid, produced from petrochemicals, often contains unwanted impurities that can lead to irritation. In contrast, Phycus’s fermentation approach utilizes upcycled, FSC-certified wood and waste molasses as feedstocks, closing the carbon cycle while reducing the reliance on petrochemicals.

Research Findings on Irritation and Effectiveness
Phycus conducted an IL-1α irritation study comparing Purolic Acid against conventional glycolic acids. The findings suggested a statistically significant reduction in irritation markers for Purolic Acid, indicating that it’s gentler on the skin. Interestingly, this fermentation-based glycolic acid also demonstrated superior performance against many established fruit extracts, which are favored alternatives for those looking to avoid synthetic chemicals. Vikram emphasizes that unlike multi-component fruit extracts, Purolic Acid provides a purer product while ensuring lower irritation potential.

Navigating the Natural and Synthetic Debate
The idea that glycolic acid is a “fruit acid” has remained entrenched in consumer perception, leading to misconceptions about its natural origins. Despite this ongoing greenwashing trend, Vikram’s assertion that the first truly natural glycolic acid is now available sheds light on a growing gap in consumer education. Notably, Phycus aims to redefine how consumers view ingredient sourcing by clarifying that "naturally occurring" does not equate to "derived from nature."

Environmental Impact and Industry Trends
Phycus’s holistic approach to sourcing and production also extends to measurable environmental impacts. Vikram claims a 40% reduction in carbon footprint compared to traditional processes, reinforced by lifecycle assessments. This shift towards quantifying sustainability metrics is an encouraging trend in the industry. Whereas previously brands relied on vague “natural” claims, there is a move toward presenting transparent data about supply chains and carbon costs.
Opportunities for Independent Brands
For indie brands, the ability to highlight scientifically-backed differences in ingredient sourcing can serve as a key differentiator in a crowded market. As more consumers increasingly gravitate toward products that promote ethical sourcing and authentic transparency, utilizing fermentation-derived ingredients like Purolic Acid could pave the way for unique positioning among competitors. This push for better ingredient choices aligns well with the ongoing demand for more sustainable and effective skincare solutions.
Meet Vikram Pandit
Vikram Pandit, as the co-founder and CEO of Phycus Biotechnologies, holds extensive qualifications in both metabolic and chemical engineering, including a PhD from the University of Toronto. Founded in 2017, Phycus is committed to developing sustainable, fermentation-based ingredient alternatives for cosmetics, with Purolic Acid standing as their flagship offering.
Learn more about Phycus Biotechnologies:
- Website: phycusbio.com
- LinkedIn: Phycus Biotechnologies
Related Episodes
- Episode 311: The palm oil alternative that doesn’t rely on trees
- Episode 319: Your skincare is made from fossil fuels
Join us on Apple Podcasts, Spotify, or YouTube for more insights on the evolving landscape of green beauty.